Forthcoming Issue Vol. 20 No. 2 RED CELL DISTRIBUTION WIDTH AS A BIOMARKER FOR PREDICTING SEVERITY AND OUTCOME IN CRITICALLY ILL CHILDREN
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Abstract
Abstract
Background: Red cell distribution width is easily available in routine haemogram reports but there is scarce literature from India regarding its role as a prognostic tool for critically ill children.
Materials and method: This was a tertiary care Paediatric Intensive Care Unit (PICU) based observational study. Laboratory variables included for study were complete blood count, serum electrolytes, mechanical ventilation days, need for inotropes and blood transfusion, duration of PICU stay and final outcome (discharge or death). Paediatric risk of mortality scoring (PRISM) III was done in all hospital admissions.
Results: There was significant association between requirement of oxygen support and mechanical ventilation in higher red cell distribution width (RDW) groups (p value 0.034 and <0.001). There was significant association between high RDW values and thrombocytopenia and leucocytosis (p value 0.034 and <0.001). High RDW values were significantly associated with increased mortality and length of stay and high PRISM scores (p values <0.001, <0.001, <0.001 respectively) in hospital.
Conclusion: RDW can be used as potentially inexpensive and easily available laboratory biomarker for identifying the severe morbidity children admitted to paediatric ICUs in low resource settings.
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