Catalysing future research on the under-recognised burden of post-tuberculosis pulmonary hypertension

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Published: 2026-03-31
DOI: https://doi.org/10.7196/AJTCCM.2026.v32i1.4992

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R Perumal
South African Medical Research Council and Centre for the AIDS Programme of Research in South Africa (SAMRC-CAPRISA) HIV-TB Pathogenesis and Treatment Research Unit, Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa; Department of Pulmonology and Critical Care, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal,Durban, South Africa

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AJTCCM Vol. 32 No. 1

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Editorials
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1.
Perumal R. Catalysing future research on the under-recognised burden of post-tuberculosis pulmonary hypertension. Afr J Thoracic Crit Care Med [Internet]. 2026 Mar. 31 [cited 2026 Apr. 21];32(1):e4992. Available from: https://www.samajournals.co.za/index.php/ajtccm/article/view/4992

References

1. Perumal R, Pillay S, Bagratee N, et al. Anatomical and functional characteristics of symptomatic post-TB lung disease. Int J Tuberc Lung Dis 2025;29(10):434-440. https://doi.org/10.5588/ijtld.25.0137

2. Menzies NA, Quaife M, Allwood BW, et al. Lifetime burden of disease due to incident tuberculosis: A global reappraisal including post-tuberculosis sequelae. Lancet Glob Health 2021;9(12):e1679-e1687. https://doi.org/10.1016/S2214-109X(21)00367-3

3. Maseko TG, Ngubane S, Letsoalo M, et al. Higher plasma interleukin-6 levels are associated with lung cavitation in drug-resistant tuberculosis. BMC Immunol 2023;24(1):26. https://doi.org/10.1186/s12865-023-00563-2

4. Thienemann F, Katoto P, Azibani F, et al. Long-term follow-up of human immunodeficiency virus-associated pulmonary hypertension: Clinical features and survival outcomes of the Pan Africa Pulmonary Hypertension Cohort (PAPUCO). Open Forum Infect Dis 2022;9(12):ofac604. https://doi.org/10.1093/ofid/ofac604

5. LouwE,BainesN,MaarmanG,etal.Theprevalenceofpulmonaryhypertensionafter successful tuberculosis treatment in a community sample of adult patients. Pulm Circ 2023;13(1):e12184. https://doi.org/10.1002/pul2.12184

6. Payne C, Louw E, Baines N, et al. Severely reduced antioxidant and impaired mitochondrial biomarkers could be linked to post-tuberculosis lung disease in a cohort from South Africa. Afr J Thorac Crit Care Med 2026;32(1):2827. https://doi. org/10.7196/AJTCCM.2026.v32i1.2827

7. Auld SC, Barczak AK, Bishai W, et al. Pathogenesis of post-tuberculosis lung disease: Defining knowledge gaps and research priorities at the Second International Post- Tuberculosis Symposium. Am J Resp Crit Care Med 2024;210(8):979-993. https:// doi.org/10.1164/rccm.202402-0374SO