Dupilumab, Asthma, and Lymphoma - Signal or Surveillance Bias?

M F Abdullah

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Published: 2026-03-31

M F Abdullah

Pulmonology Fellow, Department of Pulmonology, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa

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AJTCCM Vol. 32 No. 1

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Breath-Taking News

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Abdullah MF. Dupilumab, Asthma, and Lymphoma - Signal or Surveillance Bias?. Afr J Thoracic Crit Care Med [Internet]. 2026 Mar. 31 [cited 2026 Apr. 21];32(1):e5062. Available from: https://www.samajournals.co.za/index.php/ajtccm/article/view/5062

References

1. MaKS-K,BrumbaughB,SaffRR,etal.Dupilumabandlymphomariskamongpatients with asthma: a population-based cohort study. Eur Respir J 2025;66:2500139. https:// doi.org/10.1183/13993003.00139-2025

2. Daly PO, Wessler, P. Diagnostic Challenges of Early Mycosis Fungoides in Skin of Color: A Case Report and Review. Cureus 2025;17(4):e83081. https://doi.org/10.7759/ cureus.83081

3. Park A, Wong L, Lang A, Kraus C, Anderson N, Elsensohn A. Cutaneous T-cell lymphoma following Dupilumab use: a systematic review. Int J Dermatol 2023;62(7):862-876. https://doi.org/10.1111/ijd.16388

4. Castro M, Corren J, Pavord ID, et al. Dupilumab Efficacy and Safety in Moderate- to-Severe Uncontrolled Asthma. N Engl J Med 2018;378(26):2486-2496. https://doi. org/10.1056/NEJMoa1804092

5. Rabe KF, Nair P, Brusselle G, et al. Efficacy and Safety of Dupilumab in Glucocorticoid- Dependent Severe Asthma. N Engl J Med 2018;378(26):2475-2485. https://doi. org/10.1056/NEJMoa1804093

6. MasperoJF,PetersAT,ChapmanKR,etal.Long-TermSafetyofDupilumabinPatients with Moderate-to-Severe Asthma: TRAVERSE Continuation Study. J Allergy Clin Immunol Pract 2024;12(4):991-997.e6. https://doi.org/10.1016/j.jaip.2023.12.043

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Editor-in-chief

Prof K Dheda, MB BCh (Wits), FCP(SA), FCCP, PhD (Lond), FRCP (Lond). Head Department the Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Professor of Mycobacteriology and Global Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; Director, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, South Africa.

Deputy Editor

Prof C Koegelenberg, MB ChB, MMed (Int), FCP (SA), MRCP (UK), Cert Pulm (SA), PhD. Senior Specialist: Pulmonology & General Medicine, University of Stellenbosch & Tygerberg Academic Hospital, South Africa.

Section Editor: Breath-taking News

Prof E M Irusen, MB ChB, FCP(SA), PhD. Head: Division of Pulmonology Department of Medicine Faculty of Health Sciences University of Stellenbosch & Tygerberg Academic Hospital, South Africa.

President SA Thoracic Society

Prof. R Masekela, MB BCh, MMed (Paeds)Pret, Dipl Allerg (SA), PhD, FCCP. Adjunct Professor, Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, South Africa.
Expertise: Paediatrics, asthma, chronic lung disease, epidemiology

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