Engagement in antenatal and HIV care among pregnant women before and after Option B+ policy implementation in South Africa

Authors

  • C Hwang Health Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Internal Medicine, Stanford University School of Medicine, Stanford, USA https://orcid.org/0000-0001-7811-3492
  • N Jinga Health Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa https://orcid.org/0000-0001-6010-2867
  • M Dheda National Department of Health Pharmacovigilance Centre for Public Health Programmes, Pretoria, South Africa https://orcid.org/0000-0002-9355-5405
  • O Mhlongo KwaZulu-Natal Department of Health, Pietermaritzburg, South Africa
  • P Phungula KwaZulu-Natal Department of Health, Pietermaritzburg, South Africa
  • K Clouse Health Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Vanderbilt University School of Nursing, Nashville, USA; Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, USA https://orcid.org/0000-0002-0190-7398
  • M D Huffman Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, USA; The George Institute for Global Health, University of New South Wales, Sydney, Australia
  • M P Fox Health Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Global Health, Boston University School of Public Health, Boston, USA; Department of Epidemiology, Boston University School of Public Health, Boston, USA https://orcid.org/0000-0001-9887-0634
  • M Maskew Health Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa https://orcid.org/0000-0003-4238-0200

DOI:

https://doi.org/10.7196/SAMJ.2026.v116i1.2304

Keywords:

Pregnancy, antenatal care, HIV

Abstract

Background. Substantial gains have been made in South Africa (SA) in the prevention of vertical transmission of HIV over the past decade.

Objective. To determine whether engagement in antenatal and HIV care among pregnant women living with HIV (WLWH) differed after Option B+ implementation.

Methods. We analysed cohort data from a pregnancy and birth defects surveillance system in KwaZulu-Natal (KZN). We report on two co-primary outcomes related to engagement in HIV care: (i) timing and number of antenatal care (ANC) visits during the pregnancy period; and (ii) timing of antiretroviral therapy (ART) initiation (both self-reported ART use in interviews and observed initiation of treatment in maternal records). The association of policy era on the timing of ANC presentation was assessed using log-binomial regression modelling. We also report proportions initiating ART before or during pregnancy stratified by policy era.

Results. Data from 40 357 women, including 16 016 (40%) WLWH were analysed. During the Option B+ era, 24% of pregnant WLWH attended their first antenatal care visit during the first trimester, compared with 16% during the Option B era (relative risk 1.52; 95% confidence interval 1.41 - 1.64). The proportion of WLWH who initiated ART prior to pregnancy was also higher during the Option B+ era than the Option B era, though this result was limited by missing data.

Conclusion. Engagement in antenatal and HIV care improved after Option B+ implementation. In the Option B+ era, SA has made significant progress toward the goal of eliminating mother-to-child transmission of HIV.

References

1. Kuhn L, Goga AE. Moving towards elimination: Findings from the South Africa prevention of mother to child transmission evaluation (SAPMTCTE). BMC Infect Dis 2019;19(1):782. https://doi. org/10.1186/s12879-019-4334-3

2. South African Medical Research Council. Early mother-to-child transmission of HIV stats plunge. Cape Town: SAMRC, 2015. https://www.samrc.ac.za/media-release/early-mother-child-transmission- hiv-stats-plunge (accessed 6 April 2022).

3. Burton R, Giddy J, Stinson K. Prevention of mother-to-child transmission in South Africa: An ever- changing landscape. Obstet Med 2015;8(1):5-12. https://doi.org/10.1177/1753495x15570994

4. National Department of Health, South Africa, South African National AIDS Council. Clinical guidelines: PMTCT (prevention of mother-to- child transmission). Pretoria: NDoH, 2010. https:// sahivsoc.org/Files/NDOH_PMTCT Apr 2008.pdf (accessed 17 January 2023).

5. National Department of Health, South Africa. The South African antiretroviral treatment guidelines. Pretoria: NDoH, 2013. https://sahivsoc.org/Files/2013 ART Treatment Guidelines Final 25 March 2013 corrected.pdf (accessed 25 July 2024).

6. National Department of Health, South Africa. National consolidated guidelines for the prevention of mother-to-child transmission of HIV (PMTCT) and the management of HIV in children, adolescents and adults. Pretoria: NDoH, 2015. https://knowledgehub.health.gov.za/system/files/elibdownloads/2019-07/ National%2520consolidated%2520guidelines%25202015.pdf (accessed 2 August 2021)

7. World Health Organization. Programmatic update: Use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants. Geneva: WHO, 2012.

8. Townsend CL, Cortina-Borja M, Peckham CS, De Ruiter A, Lyall H, Tookey PA. Low rates of mother- to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000 - 2006. AIDS 2008;22(8):973-981. https://doi.org/10.1097/QAD.0b013e3282f9b67a

9. Jiwani SS, Amouzou A, Carvajal-Aguirre L, et al. Timing and number of antenatal care contacts in low and middle-income countries: Analysis in the countdown to 2030 priority countries. J Glob Health 2020;10(1):010502. https://doi.org/10.7189/jogh.10.010502

10. Joint United Nations Programme on HIV/AIDS. Prevailing against pandemics by putting people at the centre. Geneva: UNAIDS, 2020. https://www.unaids.org/en/resources/documents/2020/prevailing- against-pandemics (accessed 10 July 2024)

11. Mehta UC, van Schalkwyk C, Naidoo P, et al. Birth outcomes following antiretroviral exposure during pregnancy: Initial results from a pregnancy exposure registry in South Africa. South Afr J HIV Med 2019;20(1):971. https://doi.org/10.4102/sajhivmed.v20i1.971

12. Nxiweni PZ, Oladimeji KE, Nanjoh M, et al. Factors influencing the utilisation of antenatal services among women of childbearing age in South Africa. Women 2022;2(3):285-303. https://doi. org/10.3390/women2030027

13. National Department of Health, South Africa, Statistics South Africa, South African Medical Research Council. South Africa Demographic Health Survey 2016 Key Findings. Pretoria: NDoH, 2018. https:// dhsprogram.com/pubs/pdf/SR248/SR248.pdf (accessed 10 July 2024).

14. Woldesenbet S, Cheyip M, Lombard C, et al. Progress towards the UNAIDS 95-95-95 targets among pregnant women in South Africa: Results from the 2017 and 2019 National Antenatal HIV Sentinel Surveys. PLoS ONE 2022;17(7):e0271564. https://doi.org/10.1371/journal.pone.0271564

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Published

2026-02-09

Issue

Section

Research

How to Cite

1.
Jinga N, Dheda M, Mhlongo O, Phungula P, Clouse K, Huffman MD, et al. Engagement in antenatal and HIV care among pregnant women before and after Option B+ policy implementation in South Africa. S Afr Med J [Internet]. 2026 Feb. 9 [cited 2026 Apr. 19];116(1):e2304. Available from: https://www.samajournals.co.za/index.php/samj/article/view/2304